Does Supplementation with Royal Jelly Improve Oxidative Stress and Insulin Resistance in Type 2 Diabetic Patients?

• Main Authors: Farzad SHIDFAR (Author), Shima JAZAYERI (Author), Seyedeh Neda MOUSAVI (Author), Mojtaba MALEK (Author), Aghafateme HOSSEINI (Author), Basmeh KHOSHPEY (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2251-6085; 2251-6093
• Keywords: Royal Jelly; Type 2 diabetes mellitus; Insulin resistance; Total antioxidant capacity; Public aspects of medicine; RA1-1270
• Source: Iranian Journal of Public Health, Vol 44, Iss 6 (2015)

Background: Animal studies have shown antioxidant effects of Royal Jelly (RJ) and its effect on insulin resistance as the most common complication of Type 2 diabetes. This study was conducted to determine the effect of RJ intake on serum total antioxidant capacity, Malondialdehyde and insulin resistance in T2DM. Methods: In this randomized controlled trial, forty-six type 2 diabetic patients, aged 25-65 years, with BMI of 20-30 kg/m2, and HbA1c of 6-8% were included. The patients were randomly assigned to receive 1000 mg of RJ supplement or placebo, 3 times daily for 8 weeks. HOMA-IR, anthropometric measurements, fasting blood glucose, serum insulin, total antioxidant capacity and malondialdehyde level were measured. Results: In comparison with placebo, HOMA-IR decreased (P=0.015) while serum total antioxidant capacity in-creased significantly in RJ group (P=0.016). No significant difference was detected for serum insulin and MDA in two groups. Conclusions: RJ intake may have favorable effects on serum TAC and HOMA-IR in diabetic patients.