Reduced P53 staining in actinic keratosis is associated with squamous cell carcinoma: A preliminary study

• Main Authors: D R Neto Pimentel (Author), MMA Alchorne (Author), N S Michalany (Author), MAMM Abreu (Author), R C Borra (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background : Actinic keratosis (AK) is a cutaneous neoplasm caused by prolonged sun exposure, and may progress into squamous cell carcinoma (SCC). The p53 gene plays a central role in the development of SCC, and mutations in this gene are found in 90% of SCC and up to 100% of AK cases. Objective: To...