STUDY OF TENASCIN-C (TN-C) PROTEIN ROLE IN ORAL MALIGNANCY PROGRESSIVITY PROCESS BY MOLECULAR BIOLOGICAL APPROACH
<p>The progressiveness of malignant tumors influenced by various complex factors. One of the important factors is Tenascin-C (Tn-C) protein, which can interact with fibrinectin as an anti adhesive or anti modulation protein. Tenascin-C is an extra cellular matrix glycoprotein (EMG), which can...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Published: |
Faculty of Dentistry, Universitas Indonesia,
2006-04-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <p>The progressiveness of malignant tumors influenced by various complex factors. One of the important factors is Tenascin-C (Tn-C) protein, which can interact with fibrinectin as an anti adhesive or anti modulation protein. Tenascin-C is an extra cellular matrix glycoprotein (EMG), which can be found in the oral tissue also as an <em>up regulator.</em> They can be associated with EMG, and strongly influenced promotion of the stromal cell as cell growth, migration, differentiation, angiogenesis, and apoptosis in cancer. Alternative splicing of fibronectin-like type III (FN III) repeats of Tn-C generates a number of splice variants, and influences tumor progressiveness. The conclusion of Tn-C role in tumor progressiveness depends on the molecular weight and alternative splicing of FN III.</p> |
|---|---|
| Item Description: | 1693-9697 2355-4800 10.14693/jdi.v13i1.286 |