The rates of major malformations after gestational exposure to isotretinoin: a systematic review and meta-analysis

Objective Isotretinoin is among the most notorious human teratogens, documented originally as causing up to 30% of malformations. This systematic review and meta-analysis aimed to evaluate the rates of major malformation (MM) among isotretinoin-exposed pregnant women over the years through a systema...

Full description

Saved in:
Bibliographic Details
Main Authors: Eun Jeong Choi (Author), NaeRy Kim (Author), Ho-Seok Kwak (Author), Hae Ji Han (Author), Kyoung-Chul Chun (Author), Young-Ah Kim (Author), Jae-Whoan Koh (Author), Jung Yeol Han (Author), Sung Hong Joo (Author), Ji Sung Lee (Author), Gideon Koren (Author)
Format: Book
Published: Korean Society of Obstetrics and Gynecology, 2021-07-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_c632a0c9eb50418d8cc7f134e96ebfc0
042 |a dc 
100 1 0 |a Eun Jeong Choi  |e author 
700 1 0 |a NaeRy Kim  |e author 
700 1 0 |a Ho-Seok Kwak  |e author 
700 1 0 |a Hae Ji Han  |e author 
700 1 0 |a Kyoung-Chul Chun  |e author 
700 1 0 |a Young-Ah Kim  |e author 
700 1 0 |a Jae-Whoan Koh  |e author 
700 1 0 |a Jung Yeol Han  |e author 
700 1 0 |a Sung Hong Joo  |e author 
700 1 0 |a Ji Sung Lee  |e author 
700 1 0 |a Gideon Koren  |e author 
245 0 0 |a The rates of major malformations after gestational exposure to isotretinoin: a systematic review and meta-analysis 
260 |b Korean Society of Obstetrics and Gynecology,   |c 2021-07-01T00:00:00Z. 
500 |a 2287-8572 
500 |a 2287-8580 
500 |a 10.5468/ogs.20373 
520 |a Objective Isotretinoin is among the most notorious human teratogens, documented originally as causing up to 30% of malformations. This systematic review and meta-analysis aimed to evaluate the rates of major malformation (MM) among isotretinoin-exposed pregnant women over the years through a systematic review and meta-analysis. Methods Eligible studies were searched and identified using various databases. Single-arm meta-analysis and meta-analysis of odd ratios among controlled studies were performed using Review Manager version 5.3. Results Ten eligible studies that combined 2,783 isotretinoin-exposed women were included in our study. The rate of MM weighted for the sample size was 15%. Three studies that included an unexposed comparison group were eligible for the meta-analysis. The pooled odds ratio of MM for isotretinoin-exposed women was 3.76. After 2006, the pooled odds ratio of MM for isotretinoin exposure was significantly lower at 1.04. Conclusion The current rate of MM in isotretinoin-exposed women was substantially lower after 2006. 
546 |a EN 
546 |a KO 
690 |a isotretinoin 
690 |a congenital malformations 
690 |a pregnancy 
690 |a meta-analysis 
690 |a systematic review 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
655 7 |a article  |2 local 
786 0 |n Obstetrics & Gynecology Science, Vol 64, Iss 4, Pp 364-373 (2021) 
787 0 |n http://ogscience.org/upload/pdf/ogs-20373.pdf 
787 0 |n https://doaj.org/toc/2287-8572 
787 0 |n https://doaj.org/toc/2287-8580 
856 4 1 |u https://doaj.org/article/c632a0c9eb50418d8cc7f134e96ebfc0  |z Connect to this object online.