The rates of major malformations after gestational exposure to isotretinoin: a systematic review and meta-analysis
Objective Isotretinoin is among the most notorious human teratogens, documented originally as causing up to 30% of malformations. This systematic review and meta-analysis aimed to evaluate the rates of major malformation (MM) among isotretinoin-exposed pregnant women over the years through a systema...
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Korean Society of Obstetrics and Gynecology,
2021-07-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_c632a0c9eb50418d8cc7f134e96ebfc0 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Eun Jeong Choi |e author |
700 | 1 | 0 | |a NaeRy Kim |e author |
700 | 1 | 0 | |a Ho-Seok Kwak |e author |
700 | 1 | 0 | |a Hae Ji Han |e author |
700 | 1 | 0 | |a Kyoung-Chul Chun |e author |
700 | 1 | 0 | |a Young-Ah Kim |e author |
700 | 1 | 0 | |a Jae-Whoan Koh |e author |
700 | 1 | 0 | |a Jung Yeol Han |e author |
700 | 1 | 0 | |a Sung Hong Joo |e author |
700 | 1 | 0 | |a Ji Sung Lee |e author |
700 | 1 | 0 | |a Gideon Koren |e author |
245 | 0 | 0 | |a The rates of major malformations after gestational exposure to isotretinoin: a systematic review and meta-analysis |
260 | |b Korean Society of Obstetrics and Gynecology, |c 2021-07-01T00:00:00Z. | ||
500 | |a 2287-8572 | ||
500 | |a 2287-8580 | ||
500 | |a 10.5468/ogs.20373 | ||
520 | |a Objective Isotretinoin is among the most notorious human teratogens, documented originally as causing up to 30% of malformations. This systematic review and meta-analysis aimed to evaluate the rates of major malformation (MM) among isotretinoin-exposed pregnant women over the years through a systematic review and meta-analysis. Methods Eligible studies were searched and identified using various databases. Single-arm meta-analysis and meta-analysis of odd ratios among controlled studies were performed using Review Manager version 5.3. Results Ten eligible studies that combined 2,783 isotretinoin-exposed women were included in our study. The rate of MM weighted for the sample size was 15%. Three studies that included an unexposed comparison group were eligible for the meta-analysis. The pooled odds ratio of MM for isotretinoin-exposed women was 3.76. After 2006, the pooled odds ratio of MM for isotretinoin exposure was significantly lower at 1.04. Conclusion The current rate of MM in isotretinoin-exposed women was substantially lower after 2006. | ||
546 | |a EN | ||
546 | |a KO | ||
690 | |a isotretinoin | ||
690 | |a congenital malformations | ||
690 | |a pregnancy | ||
690 | |a meta-analysis | ||
690 | |a systematic review | ||
690 | |a Gynecology and obstetrics | ||
690 | |a RG1-991 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Obstetrics & Gynecology Science, Vol 64, Iss 4, Pp 364-373 (2021) | |
787 | 0 | |n http://ogscience.org/upload/pdf/ogs-20373.pdf | |
787 | 0 | |n https://doaj.org/toc/2287-8572 | |
787 | 0 | |n https://doaj.org/toc/2287-8580 | |
856 | 4 | 1 | |u https://doaj.org/article/c632a0c9eb50418d8cc7f134e96ebfc0 |z Connect to this object online. |