Is there an association between lymph node size and hyperprogression in immunotherapy-treated patients?

Background: Hyperprogressive disease (HPD) can be described as an accelerated increase in the growth rate of tumors combined with rapid clinical deterioration observed in a subset of cancer patients undergoing immunotherapy, specifically with immune checkpoint inhibitors (ICIs). The reported inciden...

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Main Authors: Alkader Mohammad S. (Author), Altaha Rashed Z. (Author), Jabali Eslam H. (Author), Attieh Ola A. (Author), Matalqa Ala' W. (Author)
Format: Book
Published: Sciendo, 2024-03-01T00:00:00Z.
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Summary:Background: Hyperprogressive disease (HPD) can be described as an accelerated increase in the growth rate of tumors combined with rapid clinical deterioration observed in a subset of cancer patients undergoing immunotherapy, specifically with immune checkpoint inhibitors (ICIs). The reported incidence of HPD ranges from 5.9% to 43.1% in patients receiving ICIs. In this context, identifying reliable predictive risk factors for HPD is crucial as it may allow for earlier intervention and ultimately improve patient outcomes.
Item Description:2501-062X
10.2478/rjim-2023-0025