Salivary soluble CD44 level in chronic periodontitis - A comparative assessment between preoperative and postoperative scaling and root planing

• Main Authors: Hiroj Bagde (Author), T A Abdul Salam (Author), Maha Ibrahims AlSane (Author), Maram Mohammed Almalki (Author), Reema Sultan Alshahrani (Author), Mayada Ibraheem Alhaji (Author), Halah Abdulrahman Alabdulmonem (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 0975-7406; 10.4103/jpbs.jpbs_588_22
• Keywords: chronic periodontitis; gingival index; plaque index; probing depth; salivary scd44; scaling and root planning; Pharmacy and materia medica; RS1-441; Analytical chemistry; QD71-142
• Source: Journal of Pharmacy and Bioallied Sciences, Vol 15, Iss 5, Pp 508-512 (2023)

Background: Salivary biomarkers can be used to diagnose illnesses, track their course, and gauge a patient's response to therapy. Inflammatory circumstances result in higher sCD44 levels. The most typical inflammatory disorder connected to periodontal tissue is called periodontitis. Therefore, the purpose "of the current study was to compare the levels of sCD44 in patients with chronic periodontitis before and after scaling and root planing. Objectives: 1) Determining CD44 concentrations in healthy individuals' spit. 2) To quantify CD44 levels in the saliva of individuals with persistent periodontitis. The third objective is to compare the levels of CD44 that can be dissolved in saliva between those with healthy gums and those with active periodontitis. 4) Assessing CD44 levels in saliva after "scaling and root planing in patients with chronic periodontitis." Materials and Methods: Half of the study participants were classified as having chronic periodontitis, while the other half had healthy gums. Participants with healthy gums and those with chronic periodontitis had their plaque levels, gingival status, and testing depths measured. All the same, data were calculated in persons with chronic periodontitis one month after they had "scaling and root planing done. Clinical attachment levels were evaluated before scaling and root planing was performed on patients with chronic periodontitis and again one month afterwards. Patients with chronic periodontitis," those whose condition had not improved following scaling and root planing (SRP), and healthy individuals all had spit tests conducted after a month. The concentration of sCD44 in the saliva was determined with a chemically coupled immunosorbent assay. Results: Salivary sCD44 levels were substantially greater in people with chronic periodontitis than in people without the condition. After one month of scaling and root planing in patients with chronic periodontitis, sCD44 levels drastically dropped (p < 0.0001). Conclusion: Chronic periodontitis is linked to elevated levels of salivary sCD44. sCD44 can be employed as a possible salivary biomarker for chronic Periodontitis.