Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance

• Main Authors: Muhammad Umair Amin (Author), Sajid Ali (Author), Muhammad Yasir Ali (Author), Dominik C. Fuhrmann (Author), Imran Tariq (Author), Benjamin S. Seitz (Author), Eduard Preis (Author), Jana Brüßler (Author), Bernhard Brüne (Author), Udo Bakowsky (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia, an oxygen-deprived condition of the tumor, is one of the major reasons for resistance to chemotherapy. Carbonic anhydrases are generally involved in pH homeostasis in normal conditions, but in solid tumors having a strong relation with hypoxia, the carbonic anhydrase IX (CA-IX) enzyme is ov...