Lipid-Lowering and Anti-Inflammatory Effects of <i>Campomanesia adamantium</i> Leaves in Adipocytes and <i>Caenorhabditis elegans</i>

• Main Authors: Paola dos Santos da Rocha (Author), Sarah Lam Orué (Author), Isamara Carvalho Ferreira (Author), Priscilla Pereira de Toledo Espindola (Author), Maria Victória Benites Rodrigues (Author), José Tarcísio Giffoni de Carvalho (Author), Debora da Silva Baldivia (Author), Daniel Ferreira Leite (Author), Helder Freitas dos Santos (Author), Alex Santos Oliveira (Author), Jaqueline Ferreira Campos (Author), Edson Lucas dos Santos (Author), Kely de Picoli Souza (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Obesity is a pandemic disease characterized by lipid accumulation, increased proinflammatory cytokines, and reactive oxygen species. It is associated with the development of comorbidities that lead to death. Additionally, drug treatments developed to control obesity are insufficient and have a variety of adverse effects. Thus, the search for new anti-obesity therapies is necessary. <i>Campomanesia adamantium</i> is a species from the Brazilian Cerrado that has the potential to treat obesity, as described by the antihyperlipidemic activity of its roots. Therefore, this study aimed to investigate the activity of the aqueous extract of <i>C. adamantium</i> leaves (AECa) on the control of reactive species in vitro, on lipid accumulation in adipocytes and <i>Caenorhabditis elegans</i>, and on the production of proinflammatory cytokines in adipocytes. The antioxidant capacity of AECa was observed by its action in scavenging DPPH^• free radical, iron-reducing power, and inhibition of β-carotene bleaching. AECa reduced lipid accumulation in preadipocytes and in <i>C. elegans</i>. Moreover, AECa reduced the production of the proinflammatory cytokines MCP-1, TNF-α, and IL-6 in adipocytes. In summary, the antioxidant activity and the ability of AECa to reduce the accumulation of lipids and proinflammatory cytokines indicate, for the first time, the anti-obesity potential of <i>C. adamantium</i> leaves.

Item Description

10.3390/ph17081062
1424-8247