Prehypertension in early pregnancy is a risk factor for hypertensive disorders during pregnancy: A historical cohort study in Japan

• Main Authors: Takeshi Nagao (Author), Keisuke Saito (Author), Michiko Yamanaka (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1064-1955; 1525-6065; 10.1080/10641955.2020.1864637
• Keywords: prehypertension; preterm birth; small for gestational age; hypertensive disorders of pregnancy; Gynecology and obstetrics; RG1-991
• Source: Hypertension in Pregnancy, Vol 40, Iss 1, Pp 51-55 (2021)

Objective: We evaluated the association between pre-hypertension (120-139 or 80-89 mmHg) in early pregnancy, hypertensive disorders of pregnancy (HDP), and perinatal adverse outcomes. Methods: We included 14,066 pregnant women, treated between 2003 and 2019 in Japan. Based on a blood pressure chart review recorded before 20 weeks of gestation, we stratified participants into the prehypertension (n = 3,806) and normotensive (n = 10,260) groups. Results: Prehypertension, an independent risk factor for HDP in the multivariate analysis (P< 0.001), was significantly associated with preterm and small-for-gestational age infants. Conclusion: Prehypertension potentially confers a risk for adverse perinatal outcomes in apparently normal pregnancies.