Polyphyllin VI screened from Chonglou by cell membrane immobilized chromatography relieves inflammatory pain by inhibiting inflammation and normalizing the expression of P2X3 purinoceptor

• Main Authors: Zhenhui Luo (Author), Tingting Wang (Author), Zhenglang Zhang (Author), Hekun Zeng (Author), Mengqin Yi (Author), Peiyang Li (Author), Jiaqin Pan (Author), Chunyan Zhu (Author), Na Lin (Author), Shangdong Liang (Author), Alexei Verkhratsky (Author), Hong Nie (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objective: Inflammatory pain is one of the most common diseases in daily life and clinic. In this work, we analysed bioactive components of the traditional Chinese medicine Chonglou and studied mechanisms of their analgesic effects.Material and methods: Molecular docking technology and U373 cells ov...