Methylation Profile of HOXA 11 Gene in Eutopic Endometrium on Endometriosis Patient with Infertility
Objective: To investigate the HOXA11 gene profile on endometriosis patients with infertility in Indonesia. Methods: This cross sectional study was conducted in Dr. Cipto Mangunkusumo Hospital from July 2015- June 2016. The subjects were endometriosis patients with infertility who have been confirmed...
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| Main Authors: | , , , |
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| Format: | Book |
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Indonesian Society of Obstetrics and Gynecology,
2018-04-01T00:00:00Z.
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| Summary: | Objective: To investigate the HOXA11 gene profile on endometriosis patients with infertility in Indonesia. Methods: This cross sectional study was conducted in Dr. Cipto Mangunkusumo Hospital from July 2015- June 2016. The subjects were endometriosis patients with infertility who have been confirmed histopathological. The control group was taken from non-endometriosis and fertile patients. Eutopic endometrium samples were taken and examined for the methylation of HOXA 11 gene. Results: Both groups consist of six patients. The difference of methylation of HOXA 11 gene between those two groups is statistically significant (p=0.03). There was hyper methylation in endometriosis group. Conclusion: There is a hyper methylation of HOXA 11 gene in eutopic endometrium of endometriosis patients with infertility. Thus, possibly can explain the poor endometrial receptivity in endometriosis patient and give a broad research area in epigenetic therapy of endometriosis. [Indones J Obstet Gynecol 2018; 6-2: 110-113] Keywords: endometriosis, epigenetic, HOXA 11, infertility, methylation |
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| Item Description: | 2338-6401 2338-7335 10.32771/inajog.v6i2.771 |