Protective effect of Fisetin on the lipopolysaccharide-induced preeclampsia-like rats
Objective This article is aimed to investigate the function and underlying action mechanism of Fisetin in LPS-induced PE rats. Methods LPS-induced PE-like rat model was established to explore the effects of Fisetin on PE in vivo. Results Fisetin reduced hypertension, proteinuria, TNF-α, IL-6, IL-1β,...
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| Main Authors: | , , , |
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| Format: | Book |
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Taylor & Francis Group,
2022-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Objective This article is aimed to investigate the function and underlying action mechanism of Fisetin in LPS-induced PE rats. Methods LPS-induced PE-like rat model was established to explore the effects of Fisetin on PE in vivo. Results Fisetin reduced hypertension, proteinuria, TNF-α, IL-6, IL-1β, MDA, and sFlt-1/PlGF ratio, but elevated the placental, fetal weight, GSH and SOD in PE rats. Moreover, Fisetin suppressed TLR4/NF-κB pathway, as well as promoting Nrf2/HO-1 pathway in placental tissues of PE rats. Conclusions Fisetin exerted protective role and modulated the activation of TLR4/NF-κB and Nrf2/HO-1 pathways in PE-like rat models. |
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| Item Description: | 1064-1955 1525-6065 10.1080/10641955.2021.2013874 |