Protective effect of Fisetin on the lipopolysaccharide-induced preeclampsia-like rats
Objective This article is aimed to investigate the function and underlying action mechanism of Fisetin in LPS-induced PE rats. Methods LPS-induced PE-like rat model was established to explore the effects of Fisetin on PE in vivo. Results Fisetin reduced hypertension, proteinuria, TNF-α, IL-6, IL-1β,...
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| Format: | Book |
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Taylor & Francis Group,
2022-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_c6d65a21e7e048f2a8a4e66eb6090c6b | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Ying Li |e author |
| 700 | 1 | 0 | |a Yuanyuan Liu |e author |
| 700 | 1 | 0 | |a Jinfeng Chen |e author |
| 700 | 1 | 0 | |a Jian Hu |e author |
| 245 | 0 | 0 | |a Protective effect of Fisetin on the lipopolysaccharide-induced preeclampsia-like rats |
| 260 | |b Taylor & Francis Group, |c 2022-01-01T00:00:00Z. | ||
| 500 | |a 1064-1955 | ||
| 500 | |a 1525-6065 | ||
| 500 | |a 10.1080/10641955.2021.2013874 | ||
| 520 | |a Objective This article is aimed to investigate the function and underlying action mechanism of Fisetin in LPS-induced PE rats. Methods LPS-induced PE-like rat model was established to explore the effects of Fisetin on PE in vivo. Results Fisetin reduced hypertension, proteinuria, TNF-α, IL-6, IL-1β, MDA, and sFlt-1/PlGF ratio, but elevated the placental, fetal weight, GSH and SOD in PE rats. Moreover, Fisetin suppressed TLR4/NF-κB pathway, as well as promoting Nrf2/HO-1 pathway in placental tissues of PE rats. Conclusions Fisetin exerted protective role and modulated the activation of TLR4/NF-κB and Nrf2/HO-1 pathways in PE-like rat models. | ||
| 546 | |a EN | ||
| 690 | |a preeclampsia | ||
| 690 | |a fisetin | ||
| 690 | |a inflammation | ||
| 690 | |a oxidative stress | ||
| 690 | |a tlr4/nf-κb | ||
| 690 | |a nrf2/ho-1 | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Hypertension in Pregnancy, Vol 41, Iss 1, Pp 23-30 (2022) | |
| 787 | 0 | |n http://dx.doi.org/10.1080/10641955.2021.2013874 | |
| 787 | 0 | |n https://doaj.org/toc/1064-1955 | |
| 787 | 0 | |n https://doaj.org/toc/1525-6065 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c6d65a21e7e048f2a8a4e66eb6090c6b |z Connect to this object online. |