Association of <it>ALOX5AP</it> gene single nucleotide polymorphisms and cerebral infarction in the Han population of northern China
<p>Abstract</p> <p>Background</p> <p>To explore the association of <it>ALOX5AP</it> single nucleotide polymorphisms (SNPs) and haplotype with the occurrence of cerebral infarction in the Han population of northern China.</p> <p>Methods</p>...
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2012-07-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_c6da5c9fcf2d42089c1cb2cb087ea814 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Zhang Shuang-yan |e author |
| 700 | 1 | 0 | |a Xu Mei-ling |e author |
| 700 | 1 | 0 | |a Zhang Cui-e |e author |
| 700 | 1 | 0 | |a Qu Zheng-yi |e author |
| 700 | 1 | 0 | |a Zhang Bin-bin |e author |
| 700 | 1 | 0 | |a Zheng Zu-yan |e author |
| 700 | 1 | 0 | |a Zhang Li-ming |e author |
| 245 | 0 | 0 | |a Association of <it>ALOX5AP</it> gene single nucleotide polymorphisms and cerebral infarction in the Han population of northern China |
| 260 | |b BMC, |c 2012-07-01T00:00:00Z. | ||
| 500 | |a 10.1186/1471-2350-13-61 | ||
| 500 | |a 1471-2350 | ||
| 520 | |a <p>Abstract</p> <p>Background</p> <p>To explore the association of <it>ALOX5AP</it> single nucleotide polymorphisms (SNPs) and haplotype with the occurrence of cerebral infarction in the Han population of northern China.</p> <p>Methods</p> <p>Blood samples were collected from 236 patients of Han ancestry with a history of cerebral infarction and 219 healthy subjects of Han ancestry with no history of cerebral infarction or cardiovascular disease. Applied Biosystems® TaqMan® SNP Genotyping Assays for SNP genotyping were used to determine the genotypes of 7 <it>ALOX5AP</it> SNP alleles (rs4073259, rs4769874, rs9315050, rs9551963, rs10507391, rs9579646, and rs4147064).</p> <p>Results</p> <p>One SNP allele (A) of rs4073259 was significantly associated with development of cerebral infarction (<it>P</it> = 0.049). In comparison to control groups, haplotype rs9315050&rs9551963 AAAC [OR (95% CI) =1.53 (1.02-2.29)], and genotypes rs4147064 CT [OR (95% CI) =1.872 (1.082-3.241)], and rs9551963 AC [OR (95% CI) = 2.015 (1.165-3.484)] increased the risk of cerebral infarction in patients with hypertension. Genotype rs9579646 GG [OR (95% CI) = 2.926 (1.18-7.251)] increased the risk of, while rs4073259 GG [OR (95% CI) = 0.381 (0.157-0.922)] decreased the risk of cerebral infarction in patients with diabetes.</p> <p>Conclusion</p> <p>These results suggest the <it>ALOX5AP</it> SNP A allele in rs4073259 and genotype rs9579646 GG, rs9551963 AC, and haplotype rs9315050 & rs9551963 AAAC were associated with an increased risk of ischemic stroke in the Han population, while rs4073259 GG was associated with a decreased risk.</p> | ||
| 546 | |a EN | ||
| 690 | |a Cerebral infarction | ||
| 690 | |a ALOX5AP | ||
| 690 | |a FLAP | ||
| 690 | |a Han ethnicity | ||
| 690 | |a SNP | ||
| 690 | |a Internal medicine | ||
| 690 | |a RC31-1245 | ||
| 690 | |a Genetics | ||
| 690 | |a QH426-470 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n BMC Medical Genetics, Vol 13, Iss 1, p 61 (2012) | |
| 787 | 0 | |n http://www.biomedcentral.com/1471-2350/13/61 | |
| 787 | 0 | |n https://doaj.org/toc/1471-2350 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c6da5c9fcf2d42089c1cb2cb087ea814 |z Connect to this object online. |