Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2

• Main Authors: Ao Li (Author), Dan You (Author), Wenyan Li (Author), Yingjie Cui (Author), Yingzi He (Author), Wen Li (Author), Yan Chen (Author), Xiao Feng (Author), Shan Sun (Author), Renjie Chai (Author), Huawei Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aminoglycoside-induced hair cell (HC) loss is a major cause of hearing impairment, and the effective prevention of HC loss remains an unmet medical need. Epigenetic mechanisms have been reported to be involved in protecting cochlear cells against ototoxic drug injury, and in this study we developed...