Analysis of Drug Metabolizing Gene Panel in Osteosarcoma Patients Identifies Association Between Variants in SULT1E1, CYP2B6 and CYP4F8 and Methotrexate Levels and Toxicities
High-dose methotrexate is a cornerstone agent in the chemotherapeutic treatment of patients with osteosarcoma. However, patients often develop methotrexate-induced toxicities. We aim to identify determinants of methotrexate-induced toxicities in osteosarcoma patients by investigating the relation be...
Saved in:
Main Authors: | Evelien G. E. Hurkmans (Author), Marije J. Klumpers (Author), Sita H. Vermeulen (Author), Melanie M. Hagleitner (Author), Uta Flucke (Author), H. W. Bart Schreuder (Author), Hans Gelderblom (Author), Johannes Bras (Author), Henk-Jan Guchelaar (Author), Marieke J. H. Coenen (Author), D. Maroeska W. M. te Loo (Author) |
---|---|
Format: | Book |
Published: |
Frontiers Media S.A.,
2020-08-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Inflammation altered correlation between CYP2C19 genotype and CYP2C19 activity in patients receiving voriconazole
by: Sylvia D. Klomp, et al.
Published: (2024) -
Sulfation of fulvestrant by human liver cytosols and recombinant SULT1A1 and SULT1E1
by: Edavana VK, et al.
Published: (2011) -
Effects of Saikosaponin D on CYP1A2 and CYP2D6 in HepaRG Cells
by: Li H, et al.
Published: (2020) -
SLC7A8 coding for LAT2 is associated with early disease progression in osteosarcoma and transports doxorubicin
by: Evelien G. E. Hurkmans, et al.
Published: (2022) -
Cross-species variability in lobular geometry and cytochrome P450 hepatic zonation: insights into CYP1A2, CYP2D6, CYP2E1 and CYP3A4
by: Mohamed Albadry, et al.
Published: (2024)