Interleukin-35 inhibits human umbilical vein endothelial cell injury induced by sera from pre-eclampsia patients by up-regulating S100A8 protein expression
Objectives The protective effects of interleukin(IL)-35 against injury to human umbilical vein endothelial cells (HUVECs) induced by the serum of pre-eclampsia patients were analyzed. Methods This cross-sectional study included 24 patients with pre-eclampsia (PE) and 24 normotensive pregnant women....
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| Main Authors: | , , , |
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| Format: | Book |
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Taylor & Francis Group,
2020-04-01T00:00:00Z.
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| Summary: | Objectives The protective effects of interleukin(IL)-35 against injury to human umbilical vein endothelial cells (HUVECs) induced by the serum of pre-eclampsia patients were analyzed. Methods This cross-sectional study included 24 patients with pre-eclampsia (PE) and 24 normotensive pregnant women. Results Compared to normotensive pregnant women, patients with pre-eclampsia had lower IL-35 levels (P < 0.05). In addition, our in vitro experiments, IL-35 inhibited the PE serum-induced apoptosis of HUVECs and the levels of reactive oxygen species in HUVECs. Conclusion Decreases in the serum IL-35 level may play an important role in the pathogenesis of endothelial dysfunction in patients with pre-eclampsia. |
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| Item Description: | 1064-1955 1525-6065 10.1080/10641955.2020.1744000 |