Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases
Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and present in various cells throughout the body. Its diverse physiological functions encompass glycolysis, and its abnormal activity is associated with numerous diseases. Targeting LDH has emerged as a vital approach in d...
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| Format: | Book |
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Frontiers Media S.A.,
2023-10-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_c7120c76b70d44f0bcd7a71323b5703d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Jung Ho Han |e author |
| 700 | 1 | 0 | |a Eun-Ji Lee |e author |
| 700 | 1 | 0 | |a Wonyoung Park |e author |
| 700 | 1 | 0 | |a Ki-Tae Ha |e author |
| 700 | 1 | 0 | |a Hwan-Suck Chung |e author |
| 700 | 1 | 0 | |a Hwan-Suck Chung |e author |
| 245 | 0 | 0 | |a Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases |
| 260 | |b Frontiers Media S.A., |c 2023-10-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2023.1275000 | ||
| 520 | |a Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and present in various cells throughout the body. Its diverse physiological functions encompass glycolysis, and its abnormal activity is associated with numerous diseases. Targeting LDH has emerged as a vital approach in drug discovery, leading to the identification of LDH inhibitors among natural compounds, such as polyphenols, alkaloids, and terpenoids. These compounds demonstrate therapeutic potential against LDH-related diseases, including anti-cancer effects. However, challenges concerning limited bioavailability, poor solubility, and potential toxicity must be addressed. Combining natural compounds with LDH inhibitors has led to promising outcomes in preclinical studies. This review highlights the promise of natural compounds as LDH inhibitors for treating cancer, cardiovascular, and neurodegenerative diseases. | ||
| 546 | |a EN | ||
| 690 | |a lactate dehydrogenase | ||
| 690 | |a natural compound | ||
| 690 | |a LDH inhibitor | ||
| 690 | |a pharmacological effect | ||
| 690 | |a cancer | ||
| 690 | |a cardiovascular disease | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 14 (2023) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2023.1275000/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c7120c76b70d44f0bcd7a71323b5703d |z Connect to this object online. |