Overexpression of eis without a mutation in promoter region of amikacin- and kanamycin-resistant Mycobacterium tuberculosis clinical strain

• Autori principali: Angkanang Sowajassatakul (Autore), Therdsak Prammananan (Autore), Angkana Chaiprasert (Autore), Saranya Phunpruch (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2018-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background Aminoglycosides such as amikacin and kanamycin are effective injectable second-line drugs for treatment of multidrug-resistant tuberculosis. Molecular mechanisms underlying aminoglycoside resistance are not well understood. We have previously identified the amikacin- and kanamyci...