Spare Adenosine A2a Receptors Are Associated with Positive Exercise Stress Test in Coronary Artery Disease

• Main Authors: Jean Ruf (Author), Franck Paganelli (Author), Laurent Bonello (Author), Nathalie Kipson (Author), Giovanna Mottola (Author), Julien Fromonot (Author), Jocelyne Condo (Author), Alain Boussuges (Author), Laurie Bruzzese (Author), François Kerbaul (Author), Yves Jammes (Author), Vlad Gariboldi (Author), Frédéric Franceschi (Author), Emmanuel Fenouillet (Author), Régis Guieu (Author)
• Format: Book
• Published: BMC, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract During exercise, cardiac oxygen consumption increases and the resulting low oxygen level in the myocardium triggers coronary vasodilation. This response to hypoxia is controlled notably by the vasodilator adenosine and its A2A receptor (A2AR). According to the "spare receptor" pha...