Characterization of the p.L145F and p.S135N Mutations in SOD1: Impact on the Metabolism of Fibroblasts Derived from Amyotrophic Lateral Sclerosis Patients

• Main Authors: Elisa Perciballi (Author), Federica Bovio (Author), Jessica Rosati (Author), Federica Arrigoni (Author), Angela D'Anzi (Author), Serena Lattante (Author), Maurizio Gelati (Author), Fabiola De Marchi (Author), Ivan Lombardi (Author), Giorgia Ruotolo (Author), Matilde Forcella (Author), Letizia Mazzini (Author), Sandra D'Alfonso (Author), Lucia Corrado (Author), Mario Sabatelli (Author), Amelia Conte (Author), Luca De Gioia (Author), Sabata Martino (Author), Angelo Luigi Vescovi (Author), Paola Fusi (Author), Daniela Ferrari (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of the upper and lower motor neurons (MNs). About 10% of patients have a family history (familial, fALS); however, most patients seem to develop the sporadic form of the disease (sALS). <i>SOD1&l...