RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery
Effective nose-to-brain delivery needs to be developed to treat neurodegenerative diseases. Regulating miR-124 can effectively improve the symptoms of ischemic brain injury and provide a certain protective effect from brain damage after cerebral ischemia. We used rat models of middle cerebral artery...
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| Format: | Book |
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Taylor & Francis Group,
2020-01-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_c74fce2caec94f9d9589eb973c9adb96 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Rubin Hao |e author |
| 700 | 1 | 0 | |a Bixi Sun |e author |
| 700 | 1 | 0 | |a Lihua Yang |e author |
| 700 | 1 | 0 | |a Chun Ma |e author |
| 700 | 1 | 0 | |a Shuling Li |e author |
| 245 | 0 | 0 | |a RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery |
| 260 | |b Taylor & Francis Group, |c 2020-01-01T00:00:00Z. | ||
| 500 | |a 1071-7544 | ||
| 500 | |a 1521-0464 | ||
| 500 | |a 10.1080/10717544.2020.1760960 | ||
| 520 | |a Effective nose-to-brain delivery needs to be developed to treat neurodegenerative diseases. Regulating miR-124 can effectively improve the symptoms of ischemic brain injury and provide a certain protective effect from brain damage after cerebral ischemia. We used rat models of middle cerebral artery occlusion (t-MCAO) with ischemic brain injury, and we delivered RVG29-NPs-miR124 intranasally to treat neurological damage after cerebral ischemia. Rhoa and neurological scores in rats treated by intranasal administration of RVG29-PEG-PLGA/miRNA-124 were significantly lower than those in PEG-PLGA/miRNA-124 nasal administration and RVG29-PLGA/miRNA-124 nasal administration group treated rats. These results indicate that the nose-to-brain delivery of PLGA/miRNA-124 conjugated with PEG and RVG29 alleviated the symptoms of cerebral ischemia-reperfusion injury. Thus, nasal delivery of RVG29-PEG-PLGA/miRNA-124 could be a new method for treating neurodegenerative diseases. | ||
| 546 | |a EN | ||
| 690 | |a nose-to-brain | ||
| 690 | |a ischemic brain injury | ||
| 690 | |a mirna | ||
| 690 | |a rvg29 | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Drug Delivery, Vol 27, Iss 1, Pp 772-781 (2020) | |
| 787 | 0 | |n http://dx.doi.org/10.1080/10717544.2020.1760960 | |
| 787 | 0 | |n https://doaj.org/toc/1071-7544 | |
| 787 | 0 | |n https://doaj.org/toc/1521-0464 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c74fce2caec94f9d9589eb973c9adb96 |z Connect to this object online. |