Soluble ST2 levels are associated with bleeding in patients with severe Leptospirosis.

• Main Authors: Jiri F P Wagenaar (Author), M Hussein Gasem (Author), Marga G A Goris (Author), Mariska Leeflang (Author), Rudy A Hartskeerl (Author), Tom van der Poll (Author), Cornelis van 't Veer (Author), Eric C M van Gorp (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Severe leptospirosis features bleeding and multi-organ failure, leading to shock and death. Currently it is assumed that both exaggerated inflammation and immune suppression contribute to mortality in sepsis. Indeed, several proinflammatory cytokines are reported to be induced during leptospirosis....