Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods

• Main Authors: Chantel I. Nicolas (Author), Matthew W. Linakis (Author), Melyssa S. Minto (Author), Kamel Mansouri (Author), Rebecca A. Clewell (Author), Miyoung Yoon (Author), John F. Wambaugh (Author), Grace Patlewicz (Author), Patrick D. McMullen (Author), Melvin E. Andersen (Author), Harvey J. Clewell III (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Current computational technologies hold promise for prioritizing the testing of the thousands of chemicals in commerce. Here, a case study is presented demonstrating comparative risk-prioritization approaches based on the ratio of surrogate hazard and exposure data, called margins of exposure (MoEs)...