Limitations of mouse models for sickle cell disease conferred by their human globin transgene configurations
We characterized the human β-like globin transgenes in two mouse models of sickle cell disease (SCD) and tested a genome-editing strategy to induce red blood cell fetal hemoglobin (HbF; α2γ2). Berkeley SCD mice contain four to 22 randomly arranged, fragmented copies of three human transgenes (HBA1,...
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| Main Authors: | , , , , , , , , , |
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| Format: | Book |
| Published: |
The Company of Biologists,
2022-06-01T00:00:00Z.
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