Potential of Trachyspermum ammi (ajwain) Gel for Treatment of Facial Acne vulgaris: a Pilot Study with Skin Biophysical Profile Assessment and Red Fluorescence Photography
<strong><span class="s20"><span class="bumpedFont20">Background and objectives: </span></span></strong><span class="s4"><span class="bumpedFont20">Acne vulgaris is one of the most common dermatologic conditions&l...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
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Iranian Society of Pharmacognosy,
2020-04-01T00:00:00Z.
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| Summary: | <strong><span class="s20"><span class="bumpedFont20">Background and objectives: </span></span></strong><span class="s4"><span class="bumpedFont20">Acne vulgaris is one of the most common dermatologic conditions</span></span><span class="s21"><span class="bumpedFont20">.</span></span><span class="s4"><span class="bumpedFont20"> The available anti-acne treatments are not satisfactory and safe. In this regard, searching for new treatments, especially natural materials </span></span><span class="s4"><span class="bumpedFont20">with reasonable side effects and satisfactory effectiveness</span></span><span class="s4"><span class="bumpedFont20">, could be promising. The aim of the present study was to explore the safety and efficacy of a topical formulation containing </span></span><span class="s22"><span class="bumpedFont20">Trachyspermum ammi</span></span><span class="s4"><span class="bumpedFont20"> (ajwain)</span></span><span class="s20"><span class="bumpedFont20"> </span></span><span class="s4"><span class="bumpedFont20">fruits essential oil in patients with facial acne. </span></span><strong><span class="s20"><span class="bumpedFont20">Methods:</span></span></strong><span class="s4"><span class="bumpedFont20"><strong> </strong>The essential oil of the fruits </span></span><span class="s4"><span class="bumpedFont20">was</span></span><span class="s4"><span class="bumpedFont20"> extracted by hydrodistillation method and formulated as a 1% gel</span></span><span class="s4"><span class="bumpedFont20">.</span></span><span class="s4"><span class="bumpedFont20"> </span></span><span class="s4"><span class="bumpedFont20">In this open-labeled, uncontrolled clinical trial, 20 patients with mild to moderate acne received topical ajwain gel twice daily for 8 weeks. The outcomes of acne lesion count, red fluorescence parameters and biophysical skin profiles were evaluated at baseline, 4</span></span><span class="s23"><span class="bumpedFont20">th</span></span><span class="s4"><span class="bumpedFont20"> and 8</span></span><span class="s23"><span class="bumpedFont20">th</span></span><span class="s4"><span class="bumpedFont20"> weeks. Any adverse reaction was recorded during the study. </span></span><strong><span class="s20"><span class="bumpedFont20">Results: </span></span></strong><span class="s4"><span class="bumpedFont20">All patients completed the study. Two months after treatment, the mean reduction in the total (8.2±3.36; </span></span><span class="s22"><span class="bumpedFont20">P</span></span><span class="s4"><span class="bumpedFont20">=0.000) and non-inflammatory (7.3±4.53; </span></span><span class="s22"><span class="bumpedFont20">p</span></span><span class="s4"><span class="bumpedFont20">=0.000) lesions was statistically significant. Furthermore, a significant reduction in the size and quantity of red fluorescence spots was also observed. Biophysical skin profile measurements revealed a significant reduction in erythema (</span></span><span class="s22"><span class="bumpedFont20">p</span></span><span class="s4"><span class="bumpedFont20">=0.033) and sebum (</span></span><span class="s22"><span class="bumpedFont20">p</span></span><span class="s4"><span class="bumpedFont20">=0.026) and a significant increase in pH (</span></span><span class="s22"><span class="bumpedFont20">p</span></span><span class="s4"><span class="bumpedFont20">=0.005). No serious adverse events were reported. </span></span><strong><span class="s20"><span class="bumpedFont20">Conclusion: </span></span></strong><span class="s4"><span class="bumpedFont20">The results of this pilot study provided a basis for the effectiveness of topical ajwain gel for the treatment of mild to moderate facial acne. Conducting further double blind clinical trials are necessary to confirm the efficacy and safety of the product.</span></span><br /> <span> </span> |
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| Item Description: | 2345-4458 2345-5977 10.22127/rjp.2020.104701 |