Mechanisms of action of the BCL-2 inhibitor venetoclax in multiple myeloma: a literature review

Abnormal cellular apoptosis plays a pivotal role in the pathogenesis of Multiple Myeloma (MM). Over the years, BCL-2, a crucial anti-apoptotic protein, has garnered significant attention in MM therapeutic research. Venetoclax (VTC), a small-molecule targeted agent, effectively inhibits BCL-2, promot...

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Main Authors: Qiang Cao (Author), Xinyan Wu (Author), Qi Zhang (Author), Junling Gong (Author), Yuquan Chen (Author), Yanwei You (Author), Jun Shen (Author), Yi Qiang (Author), Guangzhu Cao (Author)
Format: Book
Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
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100 1 0 |a Qiang Cao  |e author 
700 1 0 |a Qiang Cao  |e author 
700 1 0 |a Xinyan Wu  |e author 
700 1 0 |a Qi Zhang  |e author 
700 1 0 |a Junling Gong  |e author 
700 1 0 |a Yuquan Chen  |e author 
700 1 0 |a Yanwei You  |e author 
700 1 0 |a Jun Shen  |e author 
700 1 0 |a Yi Qiang  |e author 
700 1 0 |a Guangzhu Cao  |e author 
245 0 0 |a Mechanisms of action of the BCL-2 inhibitor venetoclax in multiple myeloma: a literature review 
260 |b Frontiers Media S.A.,   |c 2023-11-01T00:00:00Z. 
500 |a 1663-9812 
500 |a 10.3389/fphar.2023.1291920 
520 |a Abnormal cellular apoptosis plays a pivotal role in the pathogenesis of Multiple Myeloma (MM). Over the years, BCL-2, a crucial anti-apoptotic protein, has garnered significant attention in MM therapeutic research. Venetoclax (VTC), a small-molecule targeted agent, effectively inhibits BCL-2, promoting the programmed death of cancerous cells. While VTC has been employed to treat various hematological malignancies, its particular efficacy in MM has showcased its potential for broader clinical applications. In this review, we delve into the intricacies of how VTC modulates apoptosis in MM cells by targeting BCL-2 and the overarching influence of the BCL-2 protein family in MM apoptosis regulation. Our findings highlight the nuanced interplay between VTC, BCL-2, and MM, offering insights that may pave the way for optimizing therapeutic strategies. Through this comprehensive analysis, we aim to lay a solid groundwork for future explorations into VTC's clinical applications and the profound effects of BCL-2 on cellular apoptosis. 
546 |a EN 
690 |a cell apoptosis 
690 |a multiple myeloma 
690 |a anti-cancer drug 
690 |a cell cycle 
690 |a targeted therapies 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
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786 0 |n Frontiers in Pharmacology, Vol 14 (2023) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fphar.2023.1291920/full 
787 0 |n https://doaj.org/toc/1663-9812 
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