Mechanisms of action of the BCL-2 inhibitor venetoclax in multiple myeloma: a literature review

• Main Authors: Qiang Cao (Author), Xinyan Wu (Author), Qi Zhang (Author), Junling Gong (Author), Yuquan Chen (Author), Yanwei You (Author), Jun Shen (Author), Yi Qiang (Author), Guangzhu Cao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abnormal cellular apoptosis plays a pivotal role in the pathogenesis of Multiple Myeloma (MM). Over the years, BCL-2, a crucial anti-apoptotic protein, has garnered significant attention in MM therapeutic research. Venetoclax (VTC), a small-molecule targeted agent, effectively inhibits BCL-2, promot...