Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms

• Main Authors: Samir Mehndiratta (Author), Mei-Chuan Chen (Author), Yuh-Hsuan Chao (Author), Cheng-Hsin Lee (Author), Jing-Ping Liou (Author), Mei-Jung Lai (Author), Hsueh-Yun Lee (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8. The results indicated that substitution at C3 of quinoline is favoured for HDAC6...