Type 1 Diabetes and Addison's Disease: When the Diagnosis Is Suggested by the Continuous Glucose Monitoring System

Our objective is to emphasize the important role of continuous glucose monitoring (CGM) in suggesting adrenal insufficiency in patients affected by type 1 diabetes. We describe an adolescent girl with type 1 diabetes and subsequent latent Addison's disease diagnosed based on a recurrent hypogly...

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Main Authors: Francesco Vinci (Author), Giuseppe d'Annunzio (Author), Flavia Napoli (Author), Marta Bassi (Author), Carolina Montobbio (Author), Giulia Ferrando (Author), Nicola Minuto (Author)
Format: Book
Published: MDPI AG, 2021-08-01T00:00:00Z.
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001 doaj_c7c5860e36494866b3de7cd4a7ee85c0
042 |a dc 
100 1 0 |a Francesco Vinci  |e author 
700 1 0 |a Giuseppe d'Annunzio  |e author 
700 1 0 |a Flavia Napoli  |e author 
700 1 0 |a Marta Bassi  |e author 
700 1 0 |a Carolina Montobbio  |e author 
700 1 0 |a Giulia Ferrando  |e author 
700 1 0 |a Nicola Minuto  |e author 
245 0 0 |a Type 1 Diabetes and Addison's Disease: When the Diagnosis Is Suggested by the Continuous Glucose Monitoring System 
260 |b MDPI AG,   |c 2021-08-01T00:00:00Z. 
500 |a 10.3390/children8080702 
500 |a 2227-9067 
520 |a Our objective is to emphasize the important role of continuous glucose monitoring (CGM) in suggesting adrenal insufficiency in patients affected by type 1 diabetes. We describe an adolescent girl with type 1 diabetes and subsequent latent Addison's disease diagnosed based on a recurrent hypoglycemic trend detected by CGM. In patients with type 1 diabetes, persistent unexplained hypoglycemic episodes at dawn together with reduced insulin requirement arouse souspicionof adrenal insufficiency. Adrenal insufficiency secondary to autoimmune Addison's disease, even if rarely encountered among young patients, may be initially symptomless and characterized by slow progression up to acute adrenal crisis, which represents a potentially life-threatening condition. Besides glycometabolic assessment and adequate insulin dosage adjustment, type 1 diabetes needs prompt recognition of potentially associated autoimmune conditions. Among these, Addison's disease can be suspected, although latent or paucisymptomatic, through periodic and careful evaluation of CGM data. 
546 |a EN 
690 |a adrenal insufficiency 
690 |a type 1 diabetes 
690 |a continuous glucose monitoring 
690 |a hypoglycemia 
690 |a Schmidt's syndrome 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Children, Vol 8, Iss 8, p 702 (2021) 
787 0 |n https://www.mdpi.com/2227-9067/8/8/702 
787 0 |n https://doaj.org/toc/2227-9067 
856 4 1 |u https://doaj.org/article/c7c5860e36494866b3de7cd4a7ee85c0  |z Connect to this object online.