Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model

• Main Authors: Cheuk-Kwan Sun (Author), Yen-Yi Zhen (Author), Hung-I Lu (Author), Pei-Hsun Sung (Author), Li-Teh Chang (Author), Tzu-Hsien Tsai (Author), Jiunn-Jye Sheu (Author), Yung-Lung Chen (Author), Sarah Chua (Author), Hsueh-Wen Chang (Author), Yi-Ling Chen (Author), Fan-Yen Lee (Author), Hon-Kan Yip (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We tested the hypothesis that Lipofectamine siRNA delivery to deplete transient receptor potential cation channel (TRPC) 1 protein expression can suppress hypoxia-induced pulmonary arterial hypertension (PAH) in mice. Adult male C57BL/6 mice were equally divided into group 1 (normal controls), group...