Prospective observational study of surgery alone for locally advanced oral squamous cell carcinoma: a real-world study
Abstract Introduction A prospective observational study was modified to assess the efficacy of surgery alone for the treatment of locally advanced oral squamous cell carcinoma. (LA-OSCC) Materials and methods This prospective, single-institution, single-arm study involved 174 patients who underwent...
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| Main Authors: | , , , , , |
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| Format: | Book |
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BMC,
2024-01-01T00:00:00Z.
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| Summary: | Abstract Introduction A prospective observational study was modified to assess the efficacy of surgery alone for the treatment of locally advanced oral squamous cell carcinoma. (LA-OSCC) Materials and methods This prospective, single-institution, single-arm study involved 174 patients who underwent major surgery for LA-OSCC. Participating patients did not receive postoperative radiation. After initial curative treatment, patients were routinely monitored via clinical examination and imaging. The follow-up period was 3-70 months. Tumour recurrence and death were considered as the Clinical End Point in Research. Results The 5-year overall survival (OS), disease-free survival (DFS), and locoregional control rates for 174 patients were 66.7% (95% confidence interval [CI], 59.8 to 73.6), 66.1% (95% CI, 59.2 to 73.0), and 82.4% (95% CI, 76.5 to 88.3), respectively. Conclusion A study of patients with LA-OSCC treated with surgery alone may have the optimal therapeutic impact for LA-OSCC, as evidenced by solid data for our next RCT trial. This conclusion still needs to be validated in higher-level RCTs. |
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| Item Description: | 10.1186/s12903-024-03914-6 1472-6831 |