Sorafenib and Piperine co-loaded PLGA nanoparticles: Development, characterization, and anti-cancer activity against hepatocellular carcinoma cell line

• Main Authors: Sulaiman S. Alhudaithi (Author), Mohd Abul Kalam (Author), Lama Binobaid (Author), Raisuddin Ali (Author), Mohammed M. Almutairi (Author), Wajhul Qamar (Author), Hessa Bin Hithlayn (Author), Atheer Almutairi (Author), Abdullah K. Alshememry (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatocellular carcinoma (HCC) exhibits high mortality rates in the advanced stage (>90 %). Sorafenib (SORA) is a targeted therapy approved for the treatment of advanced HCC; however, the reported response rate to such a therapeutic is suboptimal (<3%). Piperine (PIP) is an alkaloid demonstrat...