Polypharmacology of Berberine Based on Multi-Target Binding Motifs

• Main Authors: Ming Chu (Author), Xi Chen (Author), Jing Wang (Author), Likai Guo (Author), Qianqian Wang (Author), Zirui Gao (Author), Jiarui Kang (Author), Mingbo Zhang (Author), Jinqiu Feng (Author), Qi Guo (Author), Binghua Li (Author), Chengrui Zhang (Author), Xueyuan Guo (Author), Zhengyun Chu (Author), Yuedan Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Polypharmacology is emerging as the next paradigm in drug discovery. However, considerable challenges still exist for polypharmacology modeling. In this study, we developed a rational design to identify highly potential targets (HPTs) for polypharmacological drugs, such as berberine.Meth...