Tribendimidine: mode of action and nAChR subtype selectivity in Ascaris and Oesophagostomum.

• Main Authors: Alan P Robertson (Author), Sreekanth Puttachary (Author), Samuel K Buxton (Author), Richard J Martin (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cholinergic class of anthelmintic drugs is used for the control of parasitic nematodes. One of this class of drugs, tribendimidine (a symmetrical diamidine derivative, of amidantel), was developed in China for use in humans in the mid-1980s. It has a broader-spectrum anthelmintic action against...