Exploiting the predictive power of educated spheroids to detect immune-mediated idiosyncratic drug-induced liver injury: the case of troglitazone

• Main Authors: Salomé Roux (Author), Sara Cherradi (Author), Hong Tuan Duong (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Fag: article
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Idiosyncratic drug-induced liver injury (iDILI) is a major concern in drug development because its occurrence is unpredictable. Presently, iDILI prediction is a challenge, and cell toxicity is observed only at concentrations that are much higher than the therapeutic doses in preclinical models. Appl...