Antibody-drug conjugates targeting CD248 inhibits liver fibrosis through specific killing on myofibroblasts

• Main Authors: Shaojie Liu (Author), Donghui Han (Author), Chao Xu (Author), Fa Yang (Author), Yu Li (Author), Keying Zhang (Author), Xiaolong Zhao (Author), Jiayu Zhang (Author), Tong Lu (Author), Shiqi Lu (Author), Changhong Shi (Author), Rui Zhang (Author), An-Gang Yang (Author), Aizhi Zhao (Author), Weijun Qin (Author), Bo Yang (Author), Weihong Wen (Author)
• Format: Book
• Published: BMC, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Chronic liver injury induces pathological repair, resulting in fibrosis, during which hepatic stellate cells (HSCs) are activated and transform into myofibroblasts. CD248 is mainly expressed on myofibroblasts and was considered as a promising target to treat fibrosis. The primary...