Cover Image

Establishment of a sensitive UPLC-MS/MS method to quantify safinamide in rat plasma

A fast, simple, and sensitive ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was established for the quantification of safinamide in rat plasma. Plasma samples were treated with acetonitrile for protein precipitation, and diazepam was used as an internal standar...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ying Wang (Author), Guan-An Zhao (Author), Xia Li (Author), En Zhang (Author), Wei Tan (Author), Jia-qi Chen (Author)
Format:	Book
Published:	Frontiers Media S.A., 2023-08-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

An Efficient UPLC-MS/MS Method Established to Detect Relugolix Concentration in Rat Plasma
by: Liying Xing, et al.
Published: (2022)

Highly sensitive assay for the determination of therapeutic peptide desmopressin in human plasma by UPLC-MS/MS
by: Shiva Kumar Gudlawar, et al.
Published: (2017)

Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies
by: Mengchun Chen, et al.
Published: (2020)

UPLC-MS/MS Technology for the Quantitative Methodology and Pharmacokinetic Analysis of Voxtalisib in Rat Plasma
by: Qingqing Li, et al.
Published: (2022)

Optimization of a sensitive and reliable UPLC-MS/MS method to simultaneously quantify almonertinib and HAS-719 and its application to study the interaction with nicardipine
by: Dongxin Chen, et al.
Published: (2024)

Effect of Sophocarpine on the Pharmacokinetics of Umbralisib in Rat Plasma Using a Novel UPLC-MS/MS Method
by: Qinghua Weng, et al.
Published: (2022)

Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins
by: Jiajia Dong, et al.
Published: (2021)

Development of a UPLC-MS/MS method for the determination of orelabrutinib in rat plasma and its application in pharmacokinetics
by: Ya-nan Liu, et al.
Published: (2022)

Validated UPLC-MS/MS method for quantification of fruquintinib in rat plasma and its application to pharmacokinetic study
by: Mei YB, et al.
Published: (2019)

Establishment and Verification of UPLC-MS/MS Technique for Pharmacokinetic Drug–Drug Interactions of Selinexor with Posaconazole in Rats
by: Zhou C, et al.
Published: (2021)

UPLC-MS/MS quantification of quercetin in plasma and urine following parenteral administration
by: Igor A. Zupanets, et al.
Published: (2019)

Characterization of Alpelisib in Rat Plasma by a Newly Developed UPLC-MS/MS Method: Application to a Drug-Drug Interaction Study
by: Qiong Wang, et al.
Published: (2021)

UPLC-MS/MS assay for quantification of an inhibitor of kinases (Foretinib) in plasma: Application to a pharmacokinetic study in rats
by: Essam Ezzeldin, et al.
Published: (2020)

Effect of Baicalein on the Pharmacokinetics of Cilostazol and Its Two Metabolites in Rat Plasma Using UPLC-MS/MS Method
by: Qinghua Weng, et al.
Published: (2022)

A high throughput method for Monitoring of Sorafenib, regorafenib, cabozantinib and their metabolites with UPLC-MS/MS in rat plasma
by: Er-Min Gu, et al.
Published: (2022)

Ultra-sensitive bioanalysis of the therapeutic peptide exenatide for accurate pharmacokinetic analyses at effective plasma concentrations utilizing UPLC-MS/MS
by: Max Sauter, et al.
Published: (2020)

Simultaneous UPLC-TQ-MS/MS determination of six active components in rat plasma: application in the pharmacokinetic study of Cyclocarya paliurus leaves
by: Zi-Wan Ning, et al.
Published: (2019)

Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk
by: Ayako Furugen, et al.
Published: (2023)

Application of a UPLC-MS/MS method to the protein binding study of TM-2 in rat, human and beagle dog plasma
by: Hui Liu, et al.
Published: (2016)

Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study
by: Wang MJ, et al.
Published: (2021)

Development of a robust UPLC-MS/MS method for the quantification of riluzole in human plasma and its application in pharmacokinetics
by: Zhuo Sun, et al.
Published: (2023)

Determination of lercanidipine in human plasma by an improved UPLC-MS/MS method for a bioequivalence study
by: Darshan V. Chaudhary, et al.
Published: (2016)

Pharmacokinetics of Herb-Drug Interactions of Plumbagin and Tazemetostat in Rats by UPLC-MS/MS
by: Li H, et al.
Published: (2022)

Development and validation of a UPLC-MS/MS method for simultaneous detection of doxorubicin and sorafenib in plasma: Application to pharmacokinetic studies in rats
by: Alanoud Altalal, et al.
Published: (2023)

Development of a UPLC-ESI-MS/MS method for the determination of triamcinolone acetonide in human plasma and evaluation of its bioequivalence after a single intramuscular injection in healthy volunteers
by: Pengfei Zhao, et al.
Published: (2023)

Qualitative and Quantitative Analysis of Phytochemicals in Sayeok-Tang via UPLC-Q-Orbitrap-MS and UPLC-TQ-MS/MS
by: Yu Jin Kim, et al.
Published: (2024)

UPLC-MS/MS for the determination of azilsartan in beagle dog plasma and its application in a pharmacokinetics study
by: Cheng Gong, et al.
Published: (2015)

Evaluation of the inhibitory effect of quercetin on the pharmacokinetics of tucatinib in rats by a novel UPLC-MS/MS assay
by: Ying Zhang, et al.
Published: (2022)

Simultaneous determination of multiple components in rat plasma by UPLC-MS/MS for pharmacokinetic studies after oral administration of Pogostemon cablin extract
by: Yameng Zhu, et al.
Published: (2024)

Development and validation of a UPLC-MS/MS assay for the determination of gemcitabine and its L-carnitine ester derivative in rat plasma and its application in oral pharmacokinetics
by: Gang Wang, et al.
Published: (2017)

Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS
by: Tian Lan, et al.
Published: (2021)

Simultaneous Determination of Celecoxib, Dezocine and Dexmedetomidine in Beagle Plasma Using UPLC-MS/MS Method and the Application in Pharmacokinetics
by: Hu J, et al.
Published: (2021)

Development and validation of a rapid, simple, and reliable UPLC-MS/MS method for the quantification of vancomycin in human plasma
by: Tho Do Chau Minh Vinh, et al.
Published: (2024)

Comparative Pharmacokinetics of Cinobufacini Capsule and Injection by UPLC-MS/MS
by: Ming Li, et al.
Published: (2022)

Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats
by: Yang S, et al.
Published: (2021)

Development and Validation of an Improved HPLC-MS/MS Method for Quantifying Total and Unbound Lenalidomide in Human Plasma
by: Suhyun Lee, et al.
Published: (2024)

Development of a UPLC-MS/MS method for simultaneous therapeutic drug monitoring of anti-hepatocellular carcinoma drugs and analgesics in human plasma
by: Shijia Lu, et al.
Published: (2023)

The Effect of Posaconazole and Isavuconazole on the Pharmacokinetics of Erdafitinib in Beagle Dogs by UPLC-MS/MS
by: Lan-hong Ruan, et al.
Published: (2021)

Development and Validation a UPLC-MS/MS Method for Quantification of Pentoxifylline in Beagle Plasma: Application for Pharmacokinetic Study of Food Effect
by: Xu Y, et al.
Published: (2023)

Pharmacokinetics, Bioavailability, and Tissue Distribution of the Kirsten Rat Sarcoma Inhibitor Adagrasib in Rats Using UPLC-MS/MS
by: Lei P, et al.
Published: (2024)