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Long-Term Survival and Tumor Recurrence in Patients with Superficial Esophageal Cancer after Complete Non-Curative Endoscopic Resection: A Single-Center Case Series

Background/Aims To report the long-term survival and tumor recurrence outcomes in patients with superficial esophageal cancer (SEC) after complete non-curative endoscopic resection (ER). Methods We retrieved ER data for 24 patients with non-curatively resected SEC. Non-curative resection was defined...

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Main Authors: Ji Wan Lee (Author), Charles J. Cho (Author), Do Hoon Kim (Author), Ji Yong Ahn (Author), Jeong Hoon Lee (Author), Kee Don Choi (Author), Ho June Song (Author), Sook Ryun Park (Author), Hyun Joo Lee (Author), Yong Hee Kim (Author), Gin Hyug Lee (Author), Hwoon-Yong Jung (Author), Sung-Bae Kim (Author), Jong Hoon Kim (Author), Seung-Il Park (Author)
Format: Book
Published: Korean Society of Gastrointestinal Endoscopy, 2018-09-01T00:00:00Z.
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Summary:Background/Aims To report the long-term survival and tumor recurrence outcomes in patients with superficial esophageal cancer (SEC) after complete non-curative endoscopic resection (ER). Methods We retrieved ER data for 24 patients with non-curatively resected SEC. Non-curative resection was defined as the presence of submucosal and/or lymphovascular invasion on ER pathology. Relevant clinical and tumor-specific parameters were reviewed. Results The mean age of the 24 study patients was 66.3±8.3 years. Ten patients were closely followed up without treatment, while 14 received additional treatment. During a mean follow-up of 59.0±33.2 months, the 3- and 5-year survival rates of all cases were 90.7% and 77.6%, respectively. The 5-year overall survival rates were 72.9% in the close observation group and 82.1% in the additional treatment group (p=0.958). The 5-year cumulative incidences of all cases of recurrence (25.0% vs. 43.3%, p=0.388), primary EC recurrence (10.0% vs. 16.4%, p=0.558), and metachronous EC recurrence (16.7% vs. 26.7%, p=0.667) were similar between the two groups. Conclusions Patients with non-curatively resected SEC showed good long-term survival outcomes. Given the similar oncologic outcomes, close observation may be an option with appropriate caution taken for patients who are medically unfit to receive additional therapy.
Item Description:2234-2400
2234-2443
10.5946/ce.2018.025

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