The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis
There is growing evidence that inflammation may be one of the causal factors of osteoporosis. Several cytokines such as IL-1, IL-6, RANKL, OPG, and M-CSF were implicated in the pathogenesis of osteoporosis. These cytokines are important determinants of osteoclast differentiation and its bone resorpt...
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Hindawi Limited,
2012-01-01T00:00:00Z.
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001 | doaj_c8ad91e4067c4fbf9530d6b57b4fe6e3 | ||
042 | |a dc | ||
100 | 1 | 0 | |a A. S. Nazrun |e author |
700 | 1 | 0 | |a M. Norazlina |e author |
700 | 1 | 0 | |a M. Norliza |e author |
700 | 1 | 0 | |a S. Ima Nirwana |e author |
245 | 0 | 0 | |a The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis |
260 | |b Hindawi Limited, |c 2012-01-01T00:00:00Z. | ||
500 | |a 1687-6334 | ||
500 | |a 1687-6342 | ||
500 | |a 10.1155/2012/142702 | ||
520 | |a There is growing evidence that inflammation may be one of the causal factors of osteoporosis. Several cytokines such as IL-1, IL-6, RANKL, OPG, and M-CSF were implicated in the pathogenesis of osteoporosis. These cytokines are important determinants of osteoclast differentiation and its bone resorptive activity. Anticytokine therapy using cytokine antagonists such as IL-receptor antagonist and TNF-binding protein was able to suppress the activity of the respective cytokines and prevent bone loss. Several animal studies have shown that vitamin E in the forms of palm-derived tocotrienol and α-tocopherol may prevent osteoporosis in rat models by suppressing IL-1 and IL-6. Free radicals are known to activate transcription factor NFκB which leads to the production of bone resorbing cytokines. Vitamin E, a potent antioxidant, may be able to neutralise free radicals before they could activate NFκB, therefore suppressing cytokine production and osteoporosis. Vitamin E has also been shown to inhibit COX-2, the enzyme involved in inflammatory reactions. Of the two types of vitamin E studied, tocotrienol seemed to be better than tocopherol in terms of its ability to suppress bone-resorbing cytokines. | ||
546 | |a EN | ||
690 | |a Therapeutics. Pharmacology | ||
690 | |a RM1-950 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Advances in Pharmacological Sciences, Vol 2012 (2012) | |
787 | 0 | |n http://dx.doi.org/10.1155/2012/142702 | |
787 | 0 | |n https://doaj.org/toc/1687-6334 | |
787 | 0 | |n https://doaj.org/toc/1687-6342 | |
856 | 4 | 1 | |u https://doaj.org/article/c8ad91e4067c4fbf9530d6b57b4fe6e3 |z Connect to this object online. |