The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis

There is growing evidence that inflammation may be one of the causal factors of osteoporosis. Several cytokines such as IL-1, IL-6, RANKL, OPG, and M-CSF were implicated in the pathogenesis of osteoporosis. These cytokines are important determinants of osteoclast differentiation and its bone resorpt...

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Main Authors: A. S. Nazrun (Author), M. Norazlina (Author), M. Norliza (Author), S. Ima Nirwana (Author)
Format: Book
Published: Hindawi Limited, 2012-01-01T00:00:00Z.
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100 1 0 |a A. S. Nazrun  |e author 
700 1 0 |a M. Norazlina  |e author 
700 1 0 |a M. Norliza  |e author 
700 1 0 |a S. Ima Nirwana  |e author 
245 0 0 |a The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis 
260 |b Hindawi Limited,   |c 2012-01-01T00:00:00Z. 
500 |a 1687-6334 
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500 |a 10.1155/2012/142702 
520 |a There is growing evidence that inflammation may be one of the causal factors of osteoporosis. Several cytokines such as IL-1, IL-6, RANKL, OPG, and M-CSF were implicated in the pathogenesis of osteoporosis. These cytokines are important determinants of osteoclast differentiation and its bone resorptive activity. Anticytokine therapy using cytokine antagonists such as IL-receptor antagonist and TNF-binding protein was able to suppress the activity of the respective cytokines and prevent bone loss. Several animal studies have shown that vitamin E in the forms of palm-derived tocotrienol and α-tocopherol may prevent osteoporosis in rat models by suppressing IL-1 and IL-6. Free radicals are known to activate transcription factor NFκB which leads to the production of bone resorbing cytokines. Vitamin E, a potent antioxidant, may be able to neutralise free radicals before they could activate NFκB, therefore suppressing cytokine production and osteoporosis. Vitamin E has also been shown to inhibit COX-2, the enzyme involved in inflammatory reactions. Of the two types of vitamin E studied, tocotrienol seemed to be better than tocopherol in terms of its ability to suppress bone-resorbing cytokines. 
546 |a EN 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
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786 0 |n Advances in Pharmacological Sciences, Vol 2012 (2012) 
787 0 |n http://dx.doi.org/10.1155/2012/142702 
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856 4 1 |u https://doaj.org/article/c8ad91e4067c4fbf9530d6b57b4fe6e3  |z Connect to this object online.