Use of a synthetic biosensor for neutralizing activity-biased selection of monoclonal antibodies against atroxlysin-I, an hemorrhagic metalloproteinase from Bothrops atrox snake venom.

• Main Authors: Francisco Santos Schneider (Author), Dung Le Nguyen (Author), Karen Larissa Castro (Author), Sandra Cobo (Author), Ricardo Andrez Machado de Avila (Author), Nivia de Assis Ferreira (Author), Eladio Flores Sanchez (Author), Christophe Nguyen (Author), Claude Granier (Author), Pascale Galéa (Author), Carlos Chávez-Olortegui (Author), Franck Molina (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The snake Bothrops atrox is responsible for the majority of envenomings in the northern region of South America. Severe local effects, including hemorrhage, which are mainly caused by snake venom metalloproteinases (SVMPs), are not fully neutralized by conventional serum therapy. Little...