Interleukin-5 Potentiates Sulfidopeptide Leukotriene Production by Human Eosinophils
Interleukin-5 (IL-5) has been shown to be a selective eosinophil growth and differentiation factor. In the present study, the effect of recombinant human IL-5 on human eosinophil sulfidopeptide leukotriene production was investigated. IL-5 did not affect leukotriene synthesis in unstimulated eosinop...
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| Main Authors: | , , , , |
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| Format: | Book |
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Hindawi Limited,
1994-01-01T00:00:00Z.
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| 001 | doaj_c8bb060f88f448d29e8c5a0f39d38a02 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a A. J. M. Van Oosterhout |e author |
| 700 | 1 | 0 | |a A. Van Der Poel |e author |
| 700 | 1 | 0 | |a L. Koenderman |e author |
| 700 | 1 | 0 | |a D. Roos |e author |
| 700 | 1 | 0 | |a F. P. Nijkamp |e author |
| 245 | 0 | 0 | |a Interleukin-5 Potentiates Sulfidopeptide Leukotriene Production by Human Eosinophils |
| 260 | |b Hindawi Limited, |c 1994-01-01T00:00:00Z. | ||
| 500 | |a 0962-9351 | ||
| 500 | |a 1466-1861 | ||
| 500 | |a 10.1155/S0962935194000098 | ||
| 520 | |a Interleukin-5 (IL-5) has been shown to be a selective eosinophil growth and differentiation factor. In the present study, the effect of recombinant human IL-5 on human eosinophil sulfidopeptide leukotriene production was investigated. IL-5 did not affect leukotriene synthesis in unstimulated eosinophils. However, IL-5 potentiated leukotriene synthesis by eosinophils stimulated with serum treated zymosan (STZ) or the calcium ionophore A23187 by 69% and 135%, respectively. The priming effect of IL-5 was dose dependent, with significant stimulation occurring at 1 000 U/ml for STZ and 100-1 000 U/ml for A23187. Pre-incubation with IL-5 did not increase leukotriene synthesis further. | ||
| 546 | |a EN | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Mediators of Inflammation, Vol 3, Iss 1, Pp 53-55 (1994) | |
| 787 | 0 | |n http://dx.doi.org/10.1155/S0962935194000098 | |
| 787 | 0 | |n https://doaj.org/toc/0962-9351 | |
| 787 | 0 | |n https://doaj.org/toc/1466-1861 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c8bb060f88f448d29e8c5a0f39d38a02 |z Connect to this object online. |