A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity

• Main Authors: Eneida Turiján-Espinoza (Author), Rául Alejandro Salazar-González (Author), Edith Elena Uresti-Rivera (Author), Gloria Estela Hernández-Hernández (Author), Montserrat Ortega-Juárez (Author), Rosa Milán (Author), Diana Portales-Pérez (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Arylamine N-acetyltransferase (NAT; E.C. 2.3.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of de...