Cover Image

Thiophene-Linked 1,2,4-Triazoles: Synthesis, Structural Insights and Antimicrobial and Chemotherapeutic Profiles

The reaction of thiophene-2-carbohydrazide <b>1</b> or 5-bromothiophene-2-carbohydrazide <b>2</b> with various haloaryl isothiocyanates and subsequent cyclization by heating in aqueous sodium hydroxide yielded the corresponding 4-haloaryl-5-(thiophen-2-yl or 5-bromothiophen-2...

Full description

Saved in:

Bibliographic Details
Main Authors:	Nada A. El-Emam (Author), Mahmoud B. El-Ashmawy (Author), Ahmed A. B. Mohamed (Author), El-Sayed E. Habib (Author), Subbiah Thamotharan (Author), Mohammed S. M. Abdelbaky (Author), Santiago Garcia-Granda (Author), Mohamed A. A. Moustafa (Author)
Format:	Book
Published:	MDPI AG, 2024-08-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis, physical-chemical properties and research of acute toxicity of 1,2,4-triazole derivatives containing thiophene core
by: V. A. Salionov
Published: (2015)

Anti-tuberculosis activity research of 5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol
by: A. A. Safonov, et al.
Published: (2019)

Investigation of diuretic activity of 4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles' derivatives
by: O. A. Suhak, et al.
Published: (2018)

Acute toxicity of S-derivatives of 4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles
by: O. A. Suhak, et al.
Published: (2017)

Actoprotective activity of some 5-(thiophen-3-ylmethyl)-4-R1-1,2,4-triazole-3-thiols derivatives
by: O. A. Bihdan
Published: (2020)

A study of actoprotective activity of new 3-(thiophen-2-ylmethyl)-1H-1,2,4-triazole-5-thiol derivatives
by: A. A. Safonov
Published: (2020)

Antiradical activity of novel 4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol derivatives
by: A. A. Safonov, et al.
Published: (2021)

Antihypoxic activity of benzylidenhydrazides of 4-R-5- (thiophene-2-ylmethyl)-1,2,4-triazol-3-il)thioacetic acid
by: O. A. Suhak, et al.
Published: (2017)

Some transformations and physicochemical properties of new S-substituted 5-thiophene-(3-ylmethyl)-4R-1,2,4-triazole-3-thiols
by: A. V. Khilkovets
Published: (2021)

Investigation of physical and chemical properties of new derivatives of 5-(thiophene-3-ylmethyl)-4R-1,2,4-triazole-3-thiols
by: A. V. Khilkovets
Published: (2021)

Study acute toxicity of 4-(R-amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol in vivo
by: A. A. Safonov
Published: (2018)

Synthesis, physico-chemical properties of derivatives 3-(alkylthio)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-4-amine
by: A. A. Safonov
Published: (2018)

Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles
by: O. A. Suhak, et al.
Published: (2015)

Antibacterial and antifungal activity of derivatives 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole
by: O. A. Suhak, et al.
Published: (2015)

Synthesis and properties of bis((4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)alkanes
by: O. A. Suhak, et al.
Published: (2018)

Determination of the isotonicity 1 % solution of sodium 2-((4-amino-5-thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetate
by: D. L. Usenko, et al.
Published: (2024)

Synthesis, antimicrobial, and anti-inflammatory activity, of novel S-substituted and N-substituted 5-(1-adamantyl)-1,2,4-triazole-3-thiols
by: Al-Abdullah ES, et al.
Published: (2014)

Synthesis, physico-chemical properties of 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetohyd-razides
by: A. A. Safonov
Published: (2018)

The search of new biologically active compounds with antibacterial and antifungal activity among 1,2,4-triazole-3-thiol derivatives with the remnants of thiophene
by: V. O. Salionov, et al.
Published: (2017)

Synthesis, physical-chemical properties of 2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides
by: O. A. Suhak, et al.
Published: (2017)

Synthesis, physic and chemical properties of 2-(4-R-5-(thiophene-2-ylmethyl)-4h-1,2,4-triazole-3-ylthio)acetate acids and their salts
by: O. A. Suhak, et al.
Published: (2018)

Study of the effect of sodium 2-((4-amino-5-(thiophen-2-ylmethyl)- 4H-1,2,4-triazole-3-yl)thio)acetate toxic doses on rats heart tissue
by: A. A. Safonov, et al.
Published: (2024)

Chemical properties of amino- and thio-derivatives of 1,2,4-triazoles
by: A. G. Kaplaushenko
Published: (2015)

Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles
by: Shereen R. Mohamed
Published: (2009)

Synthesis, physical and chemical properties of 2-((4-(R-amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetic acids salts
by: А.А. Safonov, et al.
Published: (2017)

Synthesis methods of 1,2,4-triazole-3-thiones: review
by: Yu. S. Frolova, et al.
Published: (2024)

Antimicrobial and antifungal activity of new fluorophenyl-containing 1,2,4-triazoles
by: O. A. Bihdan
Published: (2021)

Biological activity of the derivatives of 1,2,4-triazole
by: T. V. Kravchenko, et al.
Published: (2018)

1,2,4-Triazoles as Important Antibacterial Agents
by: Małgorzata Strzelecka, et al.
Published: (2021)

Some transformations in a series of 4-amino-1,2,4-triazole-3-thion derivatives
by: O. A. Bihdan, et al.
Published: (2024)

Synthesis and properties of some pyrazole derivatives of 1,2,4-triazole-3-thiol
by: A. S. Hotsulia, et al.
Published: (2020)

Analysis of biological properties of 1,2,4-triazole-containing compounds (literature review)
by: A. V. Khilkovets, et al.
Published: (2022)

Catheters linked thrombosis in neonates: a single center observational study
by: Marwa Mohamed Farag, et al.
Published: (2024)

The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives
by: I. M. Bilay, et al.
Published: (2014)

New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAFV600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study
by: Wael A. A. Fadaly, et al.
Published: (2023)

Diuretic activity of some 4- and 3-thio-substituted 1,2,4-triazoles with fluorophenyl fragments
by: O. A. Bihdan, et al.
Published: (2023)

Pharmacological aspects of application of 1,2,4-triazole-3-thiol furan derivatives
by: O. A. Bihdan, et al.
Published: (2016)

Encapsulated polycaprolactone with triazole derivatives and selenium nanoparticles as promising antiproliferative and anticancer agents
by: Ahmed El-Sayed Abdelhamid, et al.
Published: (2023)

Evaluation of antioxidant activity of 1,2,4-triazole derivatives in the initiation of free radical processes
by: I. M. Bilai, et al.
Published: (2024)

Methods of synthesis of 1,2,4-triazole derivatives with methoxyphenyl and study the spectrum of their pharmacological activity
by: D. V. Dovbnia, et al.
Published: (2023)