The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline
A new spectrophotometric method has been developed for the assay of olanzapine (OLN.) in pure and dosage forms. The method is based on the diazocoupling of (OLN.) with diazotized p-nitroaniline in alkaline medium to form a stable brown colored water-soluble azo dye with a maximum absorption at 405 n...
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College of Pharmacy University of Baghdad,
2017-03-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_c8fbe00d634a404f94c9bcebe24bbe8d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Sahar R. Fadhel |e author |
| 700 | 1 | 0 | |a Najwa I. Abdulla |e author |
| 700 | 1 | 0 | |a Intidhar D. Sulaiman |e author |
| 245 | 0 | 0 | |a The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline |
| 260 | |b College of Pharmacy University of Baghdad, |c 2017-03-01T00:00:00Z. | ||
| 500 | |a 10.31351/vol25iss1pp42-49 | ||
| 500 | |a 2521-3512 | ||
| 500 | |a 1683-3597 | ||
| 520 | |a A new spectrophotometric method has been developed for the assay of olanzapine (OLN.) in pure and dosage forms. The method is based on the diazocoupling of (OLN.) with diazotized p-nitroaniline in alkaline medium to form a stable brown colored water-soluble azo dye with a maximum absorption at 405 nm. The variables that affect the completion of reaction have been carefully optimized. Beer’s law is obeyed over the concentration range of (0.5-45.0 μg.mL-1) with a molar absorptivity of 1.5777Ã-104 L.mol-1.cm-1. The limit of detection was 0.3148 μg.mL-1 and Sandell’s sensitivity value was 0.0198 μg.cm-2. The proposed method has been applied successfully to the determination of olanzapine in tablet pharmaceutical preparations. Keywords: Spectrophotometry, Olanzapine, Diazotization, p-nitroaniline, tablet dosage form. | ||
| 546 | |a EN | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Iraqi Journal of Pharmaceutical Sciences, Vol 25, Iss 1 (2017) | |
| 787 | 0 | |n https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/359 | |
| 787 | 0 | |n https://doaj.org/toc/2521-3512 | |
| 787 | 0 | |n https://doaj.org/toc/1683-3597 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c8fbe00d634a404f94c9bcebe24bbe8d |z Connect to this object online. |