Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants

• Autori principali: Kristen E. Boyle (Autore), Zachary W. Patinkin (Autore), Allison L.B. Shapiro (Autore), Carly Bader (Autore), Lauren Vanderlinden (Autore), Katerina Kechris (Autore), Rachel C. Janssen (Autore), Rebecca J. Ford (Autore), Brennan K. Smith (Autore), Gregory R. Steinberg (Autore), Elizabeth J. Davidson (Autore), Ivana V. Yang (Autore), Dana Dabelea (Autore), Jacob E. Friedman (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2017-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Objective: Infants born to mothers with obesity have greater adiposity, ectopic fat storage, and are at increased risk for childhood obesity and metabolic disease compared with infants of normal weight mothers, though the cellular mechanisms mediating these effects are unclear. Methods: We tested th...