Renal L-2-hydroxyglutarate dehydrogenase activity promotes hypoxia tolerance and mitochondrial metabolism in Drosophila melanogaster

• Main Authors: Nader H. Mahmoudzadeh (Author), Yasaman Heidarian (Author), Jason P. Tourigny (Author), Alexander J. Fitt (Author), Katherine Beebe (Author), Hongde Li (Author), Arthur Luhur (Author), Kasun Buddika (Author), Liam Mungcal (Author), Anirban Kundu (Author), Robert A. Policastro (Author), Garrett J. Brinkley (Author), Gabriel E. Zentner (Author), Travis Nemkov (Author), Robert Pepin (Author), Geetanjali Chawla (Author), Sunil Sudarshan (Author), Aylin R. Rodan (Author), Angelo D'Alessandro (Author), Jason M. Tennessen (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The mitochondrial enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) regulates the abundance of L-2-hydroxyglutarate (L-2HG), a potent signaling metabolite capable of influencing chromatin architecture, mitochondrial metabolism, and cell fate decisions. Loss of L2hgdh activity in humans...