<i>CYP19A1 TC/CC</i> Polymorphism, along with Deletion of <i>GSTM1</i> and <i>GSTT1</i> Genes, Strongly Influences Female Infertility Risk

• Main Authors: Maria Manuel Casteleiro Alves (Author), Micaela Almeida (Author), António Hélio Oliani (Author), Luiza Breitenfeld (Author), Ana Cristina Ramalhinho (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Oxidative stress has a fundamental role in the pathophysiology of various conditions, like infertility. This case-control study was performed to assess the potential role of <i>CYP19A1</i>, <i>GSTM1</i>, and <i>GSTT1</i> in modifying individual predisposition to female infertility. Genotyping of 201 women with established infertility and 161 fertile female controls was performed, and statistical associations were analyzed. For carriers of <i>GSTM1</i> null genotype along with <i>CYP19A1 C</i> allele, there is a significant association with female infertility risk (OR 7.023; 95% CI (3.627-13.601; <i>p</i> < 0.001), and, also for carriers of <i>GSTT1</i> null genotype along with the <i>CYP19A1 TC/CC</i> genotype (OR 24.150; 95% CI (11.148-52.317; <i>p</i> < 0.001). A positive association with female infertility risk for carriers of the <i>C</i> allele in <i>CYP19A1</i> and null genotypes in <i>GTSM1</i> (OR 11.979; 95% CI (4.570-31.400; <i>p</i> < 0.001) or <i>GSTT1</i> (OR 13.169; 95% CI (4.518-38.380; <i>p</i> < 0.001) was found. When both <i>GSTs</i> are deleted, the risk of developing female infertility is significant, independently of the <i>CYP19A1</i> genotype; when all the presumed high-risk genotypes are present, we found a significant association with female infertility risk (OR 47,914; 95% CI (14,051-163,393; <i>p</i> < 0.001).

Item Description

10.3390/antiox12040940
2076-3921