Deletion of Ascl1 in pancreatic β-cells improves insulin secretion, promotes parasympathetic innervation, and attenuates dedifferentiation during metabolic stress

• Principais autores: Anna B. Osipovich (Autor), Frank Y. Zhou (Autor), Judy J. Chong (Autor), Linh T. Trinh (Autor), Mathew A. Cottam (Autor), Shristi Shrestha (Autor), Jean-Philippe Cartailler (Autor), Mark A. Magnuson (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2023-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objective: ASCL1, a pioneer transcription factor, is essential for neural cell differentiation and function. Previous studies have shown that Ascl1 expression is increased in pancreatic β-cells lacking functional KATP channels or after feeding of a high fat diet (HFD) suggesting that it may contribu...