Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells

• Main Authors: Aimée Bastidas-Ponce (Author), Sara S. Roscioni (Author), Ingo Burtscher (Author), Erik Bader (Author), Michael Sterr (Author), Mostafa Bakhti (Author), Heiko Lickert (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The transcription factors (TF) Foxa2 and Pdx1 are key regulators of beta-cell (β-cell) development and function. Mutations of these TFs or their respective cis-regulatory consensus binding sites have been linked to maturity diabetes of the young (MODY), pancreas agenesis, or diabetes susc...